Differential modulation of Kv4 kinetics by KCHIP1 splice variants.

  title={Differential modulation of Kv4 kinetics by KCHIP1 splice variants.},
  author={Diane Van Hoorick and Adam Raes and Wim Keysers and Evy Mayeur and Dirk Snyders},
  journal={Molecular and cellular neurosciences},
  volume={24 2},
The beta-subunits of the KChIP family modulate properties and expression level of Kv4 channels. We report the cloning of the first splice variant of KChIP1 (KChIP1b) which contains an extra exon, rich in aromatic residues, in the amino terminus. Both splice variants interacted equally well with Kv4.2 subunits based on confocal imaging and upregulation of current density (more than five-fold). No effects on the voltage dependence of activation or inactivation were noted. However, the effects on… CONTINUE READING