Differential modulation of K+-evoked 3H-neurotransmitter release from human neocortex by gabapentin and pregabalin

Abstract

Anticonvulsant, analgesic, and anxiolytic effects have been observed both in preclinical and clinical studies with gabapentin (GBP) and pregabalin (PGB). These drugs appear to act by binding to the α2δ subunit of voltage-sensitive Ca2+ channels (VSCC), resulting in the inhibition of neurotransmitter release. In this study, we examined the effects of GBP and… (More)
DOI: 10.1007/s00210-007-0237-8

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