Differential modulation of GABAA and NMDA receptors by α7-nicotinic receptor desensitization in cultured rat hippocampal neurons

@inproceedings{Shen2016DifferentialMO,
  title={Differential modulation of GABAA and NMDA receptors by α7-nicotinic receptor desensitization in cultured rat hippocampal neurons},
  author={Lei Shen and Wen-yu Cui and Ru-zhu Chen and Hai Wang},
  booktitle={Acta Pharmacologica Sinica},
  year={2016}
}
Aim:To explore the modulatory effect of desensitized α7-containing nicotinic receptors (α7-nAChRs) on excitatory and inhibitory amino acid receptors in cultured hippocampal neurons and to identify the mechanism underlying this effect.Methods:Whole-cell patch-clamp recordings were performed on cultured rat hippocampal neurons to measure α7-nAChR currents and to determine the role of desensitized α7-nAChRs on brain amino acid receptor activity.Results:Pulse and perfusion applications of the α7… CONTINUE READING

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