Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1.

@article{Lee2002DifferentialMO,
  title={Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1.},
  author={Amy Lee and Ruth E. Westenbroek and Françoise Haeseleer and Krzysztof Palczewski and Todd Scheuer and William A. Catterall},
  journal={Nature neuroscience},
  year={2002},
  volume={5 3},
  pages={210-7}
}
Ca(v)2.1 channels, which mediate P/Q-type Ca2+ currents, undergo Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter synaptic efficacy. Here we report that the neuronal Ca2+-binding protein 1 (CaBP1) modulates Ca(v)2.1 channels in a manner that is markedly different from modulation by CaM. CaBP1 enhances inactivation, causes a depolarizing shift in the voltage dependence of activation, and does not support Ca2+-dependent facilitation of Ca(v)2.1 channels… CONTINUE READING

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