Differential modulation of Burkholderia cenocepacia virulence and energy metabolism by the quorum-sensing signal BDSF and its synthase.

@article{Deng2009DifferentialMO,
  title={Differential modulation of Burkholderia cenocepacia virulence and energy metabolism by the quorum-sensing signal BDSF and its synthase.},
  author={Yinyue Deng and Calvin Boon and Leo Eberl and Lian-Hui Zhang},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 23},
  pages={7270-8}
}
Burkholderia cenocepacia produces the molecule cis-2-dodecenoic acid (BDSF), which was previously shown to play a role in antagonism against the fungal pathogen Candida albicans by interfering with its morphological transition. In this study, we show that production of BDSF is under stringent transcriptional control and the molecule accumulates in a cell density-dependent manner, typically found with quorum-sensing (QS) signals. B. cenocepacia mutant strain J2315 with a deleted Bcam0581 gene… CONTINUE READING

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