Differential modulation by divalent cations of [3H]MK-801 binding in brain synaptic membranes.

@article{Enomoto1992DifferentialMB,
  title={Differential modulation by divalent cations of [3H]MK-801 binding in brain synaptic membranes.},
  author={Riyo Enomoto and Kiyokazu Ogita and Derick S Han and Yukio Yoneda},
  journal={Journal of neurochemistry},
  year={1992},
  volume={59 2},
  pages={473-81}
}
Endogenous divalent cations, such as Mg2+, Ca2+, and Zn2+, differentially affected the binding of (+)-[3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imi ne maleate ([3H]MK-801) to an ion channel associated with an N-methyl-D-aspartate-sensitive subclass of excitatory amino acid receptors in different preparations of brain synaptic membranes. Both Mg2+ and Ca2+ were weak inhibitors of the binding in membranes which had not been extensively washed (nonwashed membranes), over a… CONTINUE READING

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