Differential modification of inflammatory enzymes in J774A.1 macrophages by ochratoxin A alone or in combination with lipopolysaccharide.

@article{Ferrante2008DifferentialMO,
  title={Differential modification of inflammatory enzymes in J774A.1 macrophages by ochratoxin A alone or in combination with lipopolysaccharide.},
  author={Maria Carmela Ferrante and Giuseppina Mattace Raso and Marcella Bilancione and Emanuela Esposito and Anna Iacono and Rosaria Meli},
  journal={Toxicology letters},
  year={2008},
  volume={181 1},
  pages={40-6}
}
Ochratoxin A (OTA) is a fungal metabolite with controversial immunomodulatory effects. A prolonged in vivo exposure to the mycotoxin may result in impaired immunity and decreased resistance to infections. In the present study, OTA modulation of lipopolysaccharide (LPS)-induced inflammatory process is described in the macrophagic cell line, J774A.1 in order to better understand the mechanisms underlying OTA immunotoxicity. OTA (30 nM-100 microM) induces a time and concentration dependent… CONTINUE READING

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