Differential microtubule requirements for transcytosis in MDCK cells.

  title={Differential microtubule requirements for transcytosis in MDCK cells.},
  author={Walter Hunziker and P C Male and Ira Mellman},
  journal={The EMBO journal},
  volume={9 11},
Given the role of microtubules in directing the transport of many intracellular organelles, we investigated whether intact microtubules were also required for transcytosis across epithelia. Using polarized MDCK cells expressing receptors for the Fc domain of IgG (FcRII-B2) or polymeric immunoglobulin (pIg-R), we examined the involvement of microtubules in apical to basolateral and basolateral to apical transcytosis, respectively. While depolymerization of microtubules with nocodozole had no… CONTINUE READING


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