Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery.

@article{Gunard2013DifferentialMI,
  title={Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery.},
  author={Fr{\'e}d{\'e}ric Gu{\'e}nard and Yves Deshaies and Katherine Cianflone and John G. Kral and Picard Marceau and Marie Claude Vohl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 28},
  pages={11439-44}
}
Obesity and overnutrition during pregnancy affect fetal programming of adult disease. Children born after maternal bariatric gastrointestinal bypass surgery (AMS) are less obese and exhibit improved cardiometabolic risk profiles carried into adulthood compared with siblings born before maternal surgery (BMS). This study was designed to analyze the impact of maternal weight loss surgery on methylation levels of genes involved in cardiometabolic pathways in BMS and AMS offspring. Differential… CONTINUE READING
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