Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes.

@article{Shikhman2009DifferentialME,
  title={Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes.},
  author={Alexander R. Shikhman and Diana C. Brinson and J. R. Valbracht and Martin K. Lotz},
  journal={Osteoarthritis and cartilage},
  year={2009},
  volume={17 8},
  pages={
          1022-8
        }
}
OBJECTIVE Aminosugars are commonly used to treat osteoarthritis; however, molecular mechanisms mediating their anti-arthritic activities are still poorly understood. This study analyzes facilitated transport and metabolic effects of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human articular chondrocytes. METHODS Human articular chondrocytes were isolated from knee cartilage. Facilitated transport of glucose, GlcN and GlcNAc was measured by uptake of [3H]2-deoxyglucose, [3H]GlcN… CONTINUE READING

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