Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain.

@article{Laughton2000DifferentialMR,
  title={Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain.},
  author={Jocelyn D Laughton and Yves Charnay and B Belloir and Luc Pellerin and Pierre J. Magistretti and Constantin Bouras},
  journal={Neuroscience},
  year={2000},
  volume={96 3},
  pages={619-25}
}
The role of lactate in brain energy metabolism has recently received renewed attention. Although blood-borne monocarboxylates such as lactate poorly cross the blood-brain barrier in the adult brain, lactate produced within the brain parenchyma may be a suitable substrate for brain cells. Lactate dehydrogenase is crucial for both the production and utilization of lactate. In this article, we report the regional distribution of the messenger RNAs for lactate dehydrogenase isoforms 1 and 5 in the… CONTINUE READING
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