Differential mechanisms of urethral smooth muscle relaxation by several NO donors and nitric oxide

@article{GarciaPascual1999DifferentialMO,
  title={Differential mechanisms of urethral smooth muscle relaxation by several NO donors and nitric oxide},
  author={Angeles Garcia-Pascual and Gonzalo Costa and Alicia Labad{\'i}a and Eugenio Jim{\'e}nez and Domingo Triguero},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1999},
  volume={360},
  pages={80-91}
}
We have examined the mechanisms of action of a broad spectrum of nitric oxide (NO) donors, including several S-nitrosothiols, sodium nitroprusside (SNP) and nitroglycerine (GTN), in relation to their relaxant activity of urethral smooth muscle. For all the compounds examined, NO release (in solution and in the presence of urethral tissue), relaxation responses, elevations in cGMP levels and the effect of thiol modulators were evaluated and compared with the effect of NO itself. Whilst all NO… CONTINUE READING

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The use of nitric oxide donors in pharmacological studies

Naunyn-Schmiedeberg's Archives of Pharmacology • 1998

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