Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands.

  title={Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands.},
  author={Lola Fern{\'a}ndez-Messina and Omodele Ashiru and Philippe Boutet and Sonia Ag{\"u}era-Gonz{\'a}lez and Jeremy N. Skepper and Hugh Thomson Reyburn and Mar Val{\'e}s-G{\'o}mez},
  journal={The Journal of biological chemistry},
  volume={285 12},
Tumor cells release NKG2D ligands to evade NKG2D-mediated immune surveillance. The purpose of our investigation was to explore the cellular mechanisms of release used by various members of the ULBP family. Using biochemical and cellular approaches in both transfectant systems and tumor cell lines, this paper shows that ULBP1, ULBP2, and ULBP3 are released from cells with different kinetics and by distinct mechanisms. Whereas ULBP2 is mainly shed by metalloproteases, ULBP3 is abundantly released… CONTINUE READING
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JOURNAL OF BIOLOGICAL CHEMISTRY 8551 by gest on M arch 4, 2015 hp://w w w .jb.org/ D ow nladed from Mar Valés-Gómez

  • S. Holdenrieder, P. Stieber, A. Peterfi, D. Nagel, A. Steinle, H. R. Salih
  • Cancer Immunol. Immunother
  • 2006

Eagle, manuscript in preparation. Mechanisms of ULBP Shedding 8550 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • M. M. Nociari, A. Shalev, P. Benias, C. Russo
  • J. Immunol. Methods 213,
  • 1998

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