Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats.

@article{Yamamoto2003DifferentialMA,
  title={Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats.},
  author={Mitsuyoshi Yamamoto and Munenori Otani and Dong-Mei Jia and Ken-ichiro Fukumitsu and Hiroyuki Yoshikawa and Toshiharu Akiyama and Makoto Otsuki},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={285 4},
  pages={G681-7}
}
Recent studies demonstrated that cholecystokinin (CCK) at physiological levels stimulates pancreatic enzyme secretion via a capsaicin-sensitive afferent vagal pathway. This study examined whether chemical ablation of afferent vagal fibers influences pancreatic growth and secretion in rats. Bilateral subdiaphragmatic vagal trunks were exposed, and capsaicin solution was applied. Pancreatic wet weight and pancreatic secretion and growth in response to endogenous and exogenous CCK were examined 7… CONTINUE READING
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