Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts.

@article{Lopatina2002DifferentialMA,
  title={Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts.},
  author={Nadejda G Lopatina and Joyce F Haskell and Lucy G. Andrews and Joseph C. Poole and Sabita N. Saldanha and Trygve O. Tollefsbol},
  journal={Journal of cellular biochemistry},
  year={2002},
  volume={84 2},
  pages={324-34}
}
Genomic methylation, which influences many cellular processes such as gene expression and chromatin organization, generally declines with cellular senescence although some genes undergo paradoxical hypermethylation during cellular aging and immortalization. To explore potential mechanisms for this process, we analyzed the methylating activity of three DNA methyltransferases (Dnmts) in aging and immortalized WI-38 fibroblasts. Overall maintenance methylating activity by the Dnmts greatly… CONTINUE READING

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