Differential lusitropic responsiveness to β-adrenergic stimulation in rat atrial and ventricular cardiac myocytes

@article{Freestone2000DifferentialLR,
  title={Differential lusitropic responsiveness to β-adrenergic stimulation in rat atrial and ventricular cardiac myocytes},
  author={Nicholas S. Freestone and Samo Ribaric and Marco Scheuermann and U. Mauser and Martin Paul and Roland Vetter},
  journal={Pfl{\"u}gers Archiv},
  year={2000},
  volume={441},
  pages={78-87}
}
Cardiac myocyte relaxation is brought about mainly through Ca2+ uptake into the sarcoplasmic reticulum (SR) by a Ca2+-ATPase isoform, SERCA2a. Its activity is modulated by another protein, phospholamban (PLB). The levels of both proteins differ in some mammals between atrial and ventricular myocardium and this may lead to differences in relaxation, especially under stimulatory conditions. At a concentration of 100 nM, the β-adrenergic agonist isoprenaline (ISO) accelerates the relaxation of rat… CONTINUE READING

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