Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease

@inproceedings{Deng2014DifferentialLO,
  title={Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease},
  author={Yun-Ping Deng and Ting Chi Vanessa Wong and Jim Y. Wan and Austin Reiner},
  booktitle={Front. Syst. Neurosci.},
  year={2014}
}
Motor slowing and forebrain white matter loss have been reported in premanifest Huntington's disease (HD) prior to substantial striatal neuron loss. These findings raise the possibility that early motor defects in HD may be related to loss of excitatory input to striatum. In a prior study, we showed that in the heterozygous Q140 knock-in mouse model of HD that loss of thalamostriatal axospinous terminals is evident by 4 months, and loss of corticostriatal axospinous terminals is evident at 12… CONTINUE READING

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Differential electrophysiological changes in striatal output neurons in Huntington's disease.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2011
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