Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction.

@article{Reddy2005DifferentialLO,
  title={Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction.},
  author={P. Hemachandra Reddy and Geethalakshmi Mani and Byung Sun Park and Joline Jacques and Geoffrey Murdoch and William O. Whetsell and Jeffrey Kaye and Maria Manczak},
  journal={Journal of Alzheimer's disease : JAD},
  year={2005},
  volume={7 2},
  pages={103-17; discussion 173-80}
}
The objective of our research was to determine synaptic protein levels in brain specimens from AD subjects and age-matched control subjects. Further, to determine whether presynaptic or postsynaptic compartments of neurons are preferentially affected in AD patients, we studied 3 presynaptic vesicle proteins (synaptotagmin, synaptophysin, and Rab 3A), 2 synaptic membrane proteins (Gap 43 and synaptobrevin), and 2 postsynaptic proteins (neurogranin and synaptopodin) in specimens from AD and age… CONTINUE READING