• Biology, Medicine
  • Published in Cancer research 1997

Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas.

@article{Marsh1997DifferentialLO,
  title={Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas.},
  author={Deborah J Marsh and Zimu Zheng and Jan Zedenius and Heinrich Kremer and George W. Padberg and Charlotta Larsson and Michel Longy and Charis Eng},
  journal={Cancer research},
  year={1997},
  volume={57 3},
  pages={
          500-3
        }
}
The susceptibility gene for Cowden disease (CD), an autosomal dominant inherited cancer syndrome, has recently been mapped to an approximately 6-cM interval on chromosome subband 10q22-23 between the markers D10S541 and D10S564. CD is characterized by hamartomas of many organ systems, including the thyroid, breast, skin, and gastrointestinal tract, as well as carcinoma of the thyroid and breast. Follicular thyroid adenomas and carcinomas are significant component tumors in CD; thus, we sought… CONTINUE READING

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