Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice.

@article{Renoir2008DifferentialLE,
  title={Differential long-term effects of MDMA on the serotoninergic system and hippocampal cell proliferation in 5-HTT knock-out vs. wild-type mice.},
  author={Thibault Renoir and Eleni Pa{\"i}zanis and Malika El Yacoubi and Françoise Saurini and Na{\"i}ma Hanoun and Maxette Melfort and Klaus-Peter Lesch and Michel Hamon and Laurence Lanfumey},
  journal={The international journal of neuropsychopharmacology},
  year={2008},
  volume={11 8},
  pages={
          1149-62
        }
}
Although numerous studies investigated the mechanisms underlying 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity, little is known about its long-term functional consequences on 5-HT neurotransmission in mice. This led us to evaluate the delayed effects of MDMA exposure on the 5-HT system, using in-vitro and in-vivo approaches in both 5-HTT wild-type and knock-out mice. Acute MDMA in-vitro application on slices of the dorsal raphe nucleus (DRN) induced concentration-dependent 5-HT… CONTINUE READING

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