Differential localization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis airway epithelium.

@article{Puchelle1992DifferentialLO,
  title={Differential localization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis airway epithelium.},
  author={Edith Puchelle and Dominique Gaillard and Dominique Ploton and Jocelyne Hinnrasky and C Fuchey and M C Boutterin and J. -P. Jacquot and Dominique Dreyer and Andr{\'e}a Pavirani and Wilfried Dalemans},
  journal={American journal of respiratory cell and molecular biology},
  year={1992},
  volume={7 5},
  pages={485-91}
}
Deletion of the amino acid residue Phe 508 of the cystic fibrosis transmembrane conductance regulator (CFTR) protein represents the most common mutation identified in cystic fibrosis (CF) patients. A monoclonal and a polyclonal antibody directed against different regions of CFTR were used to localize the CFTR protein in normal and CF airway epithelium derived from polyps of non-CF and CF subjects homozygous for the delta Phe 508 CFTR mutation. To identify the cellular and subcellular… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…