Differential localization of the Dictyostelium kinase DPAKa during cytokinesis and cell migration

@article{MuellerTaubenberger2002DifferentialLO,
  title={Differential localization of the Dictyostelium kinase DPAKa during cytokinesis and cell migration},
  author={Annette Mueller-Taubenberger and Till Bretschneider and Jan Faix and Angelika Konzok and Evelyn Simmeth and Igor Weber},
  journal={Journal of Muscle Research & Cell Motility},
  year={2002},
  volume={23},
  pages={751-763}
}
The Dictyostelium kinase DPAKa is a member of the p21-activated kinase (PAK) family, consisting of an N-terminal domain characterized by a coiled-coil region and proline-rich motifs, a Rac-binding CRIB-domain, and a highly conserved C-terminal kinase domain. In this study we show that cells overexpressing a C-terminal DPAKa fragment comprising the kinase domain are significantly impaired in motility and phagocytosis, whereas DPAKa-null cells display no obvious phenotypic change. We analyzed the… CONTINUE READING

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