Differential localization of SAP102 and PSD-95 is revealed in hippocampal spines using super-resolution light microscopy.

@article{Zheng2011DifferentialLO,
  title={Differential localization of SAP102 and PSD-95 is revealed in hippocampal spines using super-resolution light microscopy.},
  author={Chan-Ying Zheng and Ya-Xia Wang and Bechara Kachar and Ronald S. Petralia},
  journal={Communicative & integrative biology},
  year={2011},
  volume={4 1},
  pages={104-5}
}
Synapse-associated protein 102 (SAP102) and postsynaptic density 95 (PSD-95) are two major cytoskeleton proteins in the postsynaptic density (PSD). Both of them belong to the membrane-associated guanylate kinase (MAGUK) family, which clusters and anchors glutamate receptors and other proteins at synapses. In our previous study, we found that SAP102 and PSD-95 have different distributions, using combined light/electron microscopy (LM/EM) methods.1 Here, we double labeled endogenous SAP102 and… CONTINUE READING