Differential localization of ErbB2 in different tissues of the rat female reproductive tract: implications for the use of specific antibodies for ErbB2 analysis.

@article{Idris2001DifferentialLO,
  title={Differential localization of ErbB2 in different tissues of the rat female reproductive tract: implications for the use of specific antibodies for ErbB2 analysis.},
  author={Nebila Idris and Coralie A Carothers Carraway and Kermit L. Iii Carraway},
  journal={Journal of cellular physiology},
  year={2001},
  volume={189 2},
  pages={
          162-70
        }
}
ErbB2 has been implicated in numerous functions, including normal and aberrant development of a variety of tissues. Although no soluble ligand has been identified for ErbB2, we have recently shown that ASGP-2, the transmembrane subunit of the cell surface glycoprotein Muc4 (also called sialomucin complex, SMC), can act as an intramembrane ligand for ErbB2 and modulate its activity. Muc4/SMC is abundantly expressed at the apical surface of most epithelia of the rat female reproductive tract… CONTINUE READING
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