Differential lipoprotein transport pathways of K-vitamins in healthy subjects.

@article{Schurgers2002DifferentialLT,
  title={Differential lipoprotein transport pathways of K-vitamins in healthy subjects.},
  author={Leon J. Schurgers and Cees Vermeer},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1570 1},
  pages={
          27-32
        }
}

Figures and Tables from this paper

Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.

MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way.

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease

This review is the first to highlight differences between isoforms vitamin K1 and K2 by means of source, function, and extrahepatic activity.

Vitamin K plasma levels determination in human health

Vitamin K plays an important role as a cofactor in the synthesis of hepatic blood coagulation proteins, but recently has also aroused an increasing interest for its action in extra-hepatic tissues, in particular in the regulation of bone and vascular metabolism.

Metabolism and cell biology of vitamin K.

Many studies have shown specific clinical benefits of MK-4 at pharmacological doses for osteoporosis and cancer although the mechanism(s) are poorly understood, and a daily supplement of phylloquinone has shown potential for improving anticoagulation control.

Vitamin K Beyond Coagulation to Uses in Bone , Vascular , and Anti-Cancer Metabolism

Vitamin K is a family of structurally similar, fat-soluble 2-methyl-1,4-naphthoquinones that is primarily found in 2 forms and is the predominant form of vitamin K in the brain and all other tissues, except the liver.

A New Horizon in Vitamin K Research.

  • T. Okano
  • Biology
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2016
New insights into the molecular mechanisms underlying the intestinal absorption and in vivo tissue conversion of vitamin K1 to menaquinone-4 (MK-4) are focused on with special emphasis on two major advances in the studies of intestinal vitamin K transporters in enterocytes and a tissue MK-4 biosynthetic enzyme UBIAD1.

The role of menaquinones (vitamin K₂) in human health.

It is concluded that further investigations are needed to establish how differences among the vitamin K forms may influence tissue specificities and their role in human health, and there is merit for considering both menaquinones and phylloquinone when developing future recommendations for vitamin K intake.

Menadione is a metabolite of oral vitamin K

The present study shows that menadione is a catabolic product of K vitamins formed after oral intake, and the rapid appearance in urine after oral but not subcutaneous administration suggests that catabolism occurs during intestinal absorption.

Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis

The mechanisms and functions of vitamin K recycling and MK-4 synthesis have dominated advances made in vitamin K biochemistry over the last five years and, after a brief overview of general metabolism, are the main focuses of this review.

Tissue-Specific Utilization of Menaquinone-4 Results in the Prevention of Arterial Calcification in Warfarin-Treated Rats

The observed differences between K1 and MK-4 with respect to inhibition of arterial calcification may be explained by both differences in their tissue bioavailability and cofactor utilization in the reductase/carboxylase reaction.
...

References

SHOWING 1-10 OF 42 REFERENCES

Vitamin K metabolism and nutriture.

Plasma lipoproteins as carriers of phylloquinone (vitamin K1) in humans.

The data indicate that whereas triacylglycerol-rich lipoproteins are the major carriers of phylloquinone, LDL and HDL may carry small fractions of this vitamin.

Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4

There is selective tissue distribution of K1 and MK-4, dietary K1 is a source of menaquinone-4 and the results suggest there may be an as yet unrecognized physiological function for vitamin K (MK-4).

Role of vitamin K and vitamin K-dependent proteins in vascular calcification

The hypothesis is put forward that undercarboxylation of MGP is a risk factor for vascular calcification and that the present RDA values for vitamin K are too low to ensure full carboxylated MGP.

Whole-body autoradiographic study of vitamin K distribution in rat.

The distribution of K2 in rats by whole-body autoradiography which is advantage in determining the intuitively fine distribution of radioactivity is reported, which is compared with those of naturally occurring vitamin K1 and synthetic vitamin, vitamin K3.

Phylloquinone and menaquinone-4 distribution in rats: synthesis rather than uptake determines menaquinone-4 organ concentrations.

The study shows the following: dietary phylloquinone is accumulated mainly in the heart and liver, the MK-4 accumulation in nonhepatic organs is due to synthesis rather than uptake andMK-4 rather than phyllaquinone may be the functional vitamin in non hepatics organs.