Differential lipid affinity of xenobiotics and natural compounds.

  title={Differential lipid affinity of xenobiotics and natural compounds.},
  author={Heinrich Sandermann},
  journal={FEBS letters},
  volume={554 1-2},
Octanol-1/water partitioning currently provides the most widely used model system to simulate both phospholipid target lipids and triglyceride storage lipids. A differentiation between the two lipid classes is now achieved by making use of a water-induced lipid phase separation. Coefficients (K(TG/PC)) for partitioning between trioleoylglycerol (TG) and phosphatidylcholine (PC) were determined for 20 xenobiotics and two biological lipids. K(TG/PC) values are related to KOW through the… CONTINUE READING

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