Differential light chain assembly influences outer arm dynein motor function.

  title={Differential light chain assembly influences outer arm dynein motor function.},
  author={Linda M DiBella and Oksana I Gorbatyuk and Miho Sakato and Ken-Ichi Wakabayashi and Ramila S. Patel-King and Gregory J Pazour and George B Witman and Stephen M King},
  journal={Molecular biology of the cell},
  volume={16 12},
Tctex1 and Tctex2 were originally described as potential distorters/sterility factors in the non-Mendelian transmission of t-haplotypes in mice. These proteins have since been identified as subunits of cytoplasmic and/or axonemal dyneins. Within the Chlamydomonas flagellum, Tctex1 is a subunit of inner arm I1. We have now identified a second Tctex1-related protein (here termed LC9) in Chlamydomonas. LC9 copurifies with outer arm dynein in sucrose density gradients and is missing only in those… CONTINUE READING