Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes.

@article{Leiter2004DifferentialLO,
  title={Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes.},
  author={Edward H. Leiter and Peter C. Reifsnyder},
  journal={Diabetes},
  year={2004},
  volume={53 Suppl 1},
  pages={S4-11}
}
The genetic basis for the more common forms of human obesity predisposing to insulin resistance and development of type 2 diabetes is multigenic rather than monogenic in origin. New mouse "diabesity" models have been created by combining independent diabetes risk-conferring quantitative trait loci from two unrelated parental strains: New Zealand Obese (NZO/HlLt) and Nonobese Nondiabetic (NON/Lt). F1 hybrid males, heterozygous at all polymorphic autosomal loci distinguishing the two parental… CONTINUE READING
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