Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection.

  title={Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection.},
  author={Melissa Lynn Precopio and John L. Sullivan and Courtney Willard and Mohan Somasundaran and Katherine Luzuriaga},
  journal={Journal of immunology},
  volume={170 5},
The generation and maintenance of virus-specific CD4(+) T cells in humans are not well understood. We used short in vitro stimulation assays followed by intracellular cytokine staining to characterize the timing, magnitude, and Ag specificity of CD4(+) T cells over the course of primary EBV infection. Lytic and latent protein-specific CD4(+) T cells were readily detected at presentation with acute infectious mononucleosis and declined rapidly thereafter. Responses to BZLF-1, BMLF-1, and Epstein… CONTINUE READING

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