Differential involvement of prefrontal cortex, striatum, and hippocampus in DRL performance in mice

  title={Differential involvement of prefrontal cortex, striatum, and hippocampus in DRL performance in mice},
  author={Yoon H Cho and Yannick Jeantet},
  journal={Neurobiology of Learning and Memory},
  • Yoon H Cho, Y. Jeantet
  • Published 31 January 2010
  • Psychology, Biology
  • Neurobiology of Learning and Memory

A comparison of adult and adolescent rat behavior in operant learning, extinction, and behavioral inhibition paradigms.

Results from these experiments suggest that adolescents exhibit impaired learning, behavioral inhibition and self-control, and provide researchers with three behavioral models to more fully explore neurobiology of risk-taking behavior in adolescence.

κ-Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition

It is demonstrated that K OR activation in VTA dopamine neurons disrupts behavioral inhibition in a GRK3/arrestin-independent manner and suggests that KOR antagonists could be beneficial for decreasing stress-induced compulsive behaviors.

Performance on an impulse control task is altered in adult rats exposed to amphetamine during adolescence.

A differential reinforcement of low rates of responding task in rats to determine if amphetamine (AMPH) exposure during adolescence would alter behavioral inhibition in adulthood suggests that AMPH-induced alterations in incentive-motivation and perseveration are more robust and longer-lasting than its effects on impulse control.

Sleep restriction in rats leads to changes in operant behaviour indicative of reduced prefrontal cortex function

The results show that sleep‐restricted animals were less able to time their responses correctly, started pressing the lever more randomly and showed signs of behavioural disinhibition, the latter possibly reflecting enhanced impulsivity.

Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2

It is concluded that LPAR2 stabilizes neuronal network excitability upon aging and allows for more efficient use of resting periods, better memory consolidation and better performance in tasks requiring high selective attention.

Estradiol impairs response inhibition in young and middle-aged, but not old rats.

Prefrontal regulation of behavioural control: Evidence from learning theory and translational approaches in rodents



Functional dissociation of the prefrontal cortex and the hippocampus in timing behavior.

Using the peak procedure, rats with aspiration lesions to the medial prefrontal cortex (PFC) or the hippocampus were tested for the acquisition of timing behavior and temporal memory and concluded that neither the medial PFC nor the hippocampus is necessary for the memory of temporal events.

Selective cytotoxic lesions of the hippocampal formation and DRL performance in rats.

It is concluded that hippocampal lesions made with ibotenic acid resemble conventional hippocampusal lesions in their behavioral effects on DRL performance; that the behavioral effects of scopolamine administration do not appear to depend on disruption of activity of cholinoceptive cells in the hippocampal formation; and that DRL schedules, although highly sensitive to septohippocampal system disruption, discriminate more between the extent than the location of lesions in the system.

Functions of the frontal cortex of the rat: A comparative review

  • B. Kolb
  • Biology, Psychology
    Brain Research Reviews
  • 1984

The hippocampus, collateral behavior, and timing.

Rats with hippocampal lesions (HC), cortical control lesions, or sham operations were trained to lever press on a differential reinforcement of low rates (DRL) schedule requiring 12 sec between

Embryonic striatal grafts reverse the disinhibitory effects of ibotenic acid lesions of the ventral striatum

Grafts of embryonic striatal tissue transplanted to the lesioned ventral striatum were found to survive well and reversed the effects of the lesion on measures of conditioned and unconditioned behaviour.