Differential involvement of initiator caspases in apoptotic volume decrease and potassium efflux during Fas- and UV-induced cell death.

@article{Vu2001DifferentialIO,
  title={Differential involvement of initiator caspases in apoptotic volume decrease and potassium efflux during Fas- and UV-induced cell death.},
  author={Choua C Vu and Carl D. Bortner and John Anthony Cidlowski},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 40},
  pages={37602-11}
}
Caspase activation and apoptotic volume decrease are fundamental features of programmed cell death; however, the relationship between these components is not well understood. Here we provide biochemical and genetic evidence for the differential involvement of initiator caspases in the apoptotic volume decrease during both intrinsic and extrinsic activation of apoptosis. Apoptosis induction in Jurkat T lymphocytes by Fas receptor engagement (intrinsic) or ultraviolet (UV)-C radiation (extrinsic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Possible causes of apoptotic volume decrease: an attempt at quantitative review.

American journal of physiology. Cell physiology • 2014
View 1 Excerpt

Cell death mechanisms and their implications in toxicology.

Toxicological sciences : an official journal of the Society of Toxicology • 2011
View 1 Excerpt

Life and death of lymphocytes: a volume regulation affair.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2011

Similar Papers

Loading similar papers…