Differential involvement of CCK-A and CCK-B receptors in the regulation of locomotor activity in the mouse

@article{Vasar1991DifferentialIO,
  title={Differential involvement of CCK-A and CCK-B receptors in the regulation of locomotor activity in the mouse},
  author={E. E. Vasar and Jaanus Harro and Aavo Lang and Anu P{\~o}ld and Andres Soosaar},
  journal={Psychopharmacology},
  year={1991},
  volume={105},
  pages={393-399}
}
The influence of the CCK-A antagonist devazepide and the CCK-B/gastrin antagonist L-365,260 on the locomotor activity of mice was studied. Devazepide and L-365,260 had opposite effects on spontaneous locomotor activity, and on caerulein- and apomorphine-induced hypomotility in the mouse. Devazepide in high doses (0.1–1 mg/kg IP) reduced spontaneous motor activity, whereas L-365,260 at a high dose (1 mg/kg IP) increased the activity of mice. Devazepide (0.1–10 µg/kg) moderately antagonized the… CONTINUE READING

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