Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator.

@article{Aleksandrov2001DifferentialIO,
  title={Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator.},
  author={Luba A. Aleksandrov and April E Mengos and Xiu-bao Chang and Alexey Aleksandrov and John R. Riordan},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 16},
  pages={12918-23}
}
After phosphorylation by protein kinase A, gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is regulated by the interaction of ATP with its nucleotide binding domains (NBDs). Models of this gating regulation have proposed that ATP hydrolysis at NBD1 and NBD2 may drive channel opening and closing, respectively (reviewed in Nagel, G. (1999) Biochim. Biophys. Acta 1461, 263-274). However, as yet there has been little biochemical confirmation of the… CONTINUE READING

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