Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes

@article{Mckenna1990DifferentialIO,
  title={Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes},
  author={Dennis J. Mckenna and David Bruce Repke and Lauren Lo and Stephen J. Peroutka},
  journal={Neuropharmacology},
  year={1990},
  volume={29},
  pages={193-198}
}
Affinities of drugs for 21 indolealkylamine derivatives, some with putative hallucinogenic activity, were determined at 5-HT1A, 5-HT2A and 5-HT2B recognition sites, using radioligand competition studies. Nearly all of the derivatives displayed greatest potency for the 5-HT2A receptor, labelled by [125I]R-(-)DOI in the cortex of the rat. Most derivatives displayed 2-10 times lower affinity at the HT2B receptor labelled by [3H]ketanserin in bovine cortex. Derivatives lacking ring substituents… 
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