Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus.

@article{Hajishengallis2006DifferentialIO,
  title={Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus.},
  author={George Hajishengallis and Richard I. Tapping and Evlambia Harokopakis and So-ichiro Nishiyama and Pukar Ratti and Robert E. Schifferle and Elizabeth A. Lyle and Martha Triantafilou and Kathy Triantafilou and Fuminobu Yoshimura},
  journal={Cellular microbiology},
  year={2006},
  volume={8 10},
  pages={1557-70}
}
The lipopolysaccharide (LPS) and fimbriae of Porphyromonas gingivalis play important roles in periodontal inflammation and pathogenesis. We investigated fimbriae and LPS from several P. gingivalis strains in terms of relative dependence on Toll-like receptor (TLR) signalling partners or accessory pattern-recognition molecules mediating ligand transfer to TLRs, and determined induced assembly of receptor complexes in lipid rafts. Fimbriae could utilize TLR1 or TLR6 for cooperative TLR2-dependent… CONTINUE READING
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