Differential interactions of cytochalasins with P-glycoprotein.

  title={Differential interactions of cytochalasins with P-glycoprotein.},
  author={Jack T. Zilfou and Charles D. Smith},
  journal={Oncology research},
  volume={7 9},
Cytochalasins are a family of structurally related natural product cytotoxins that selectively depolymerize microfilaments. In this study, the interaction between several cytochalasins and the drug transporter P-glycoprotein was investigated. Dihydrocytochalasin B and cytochalasin E consistently sensitized P-glycoprotein-overexpressing human breast carcinoma cells (MCF-7/ADR) to daunomycin, vinblastine, and actinomycin D without affecting the cytotoxicity of cisplatin. These compounds did not… CONTINUE READING

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