Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes.

@article{Andersson2004DifferentialIB,
  title={Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes.},
  author={Jessica Andersson and D. M. Simpson and Maosong Qi and Yunmei Wang and Elaine A. Elion},
  journal={The EMBO journal},
  year={2004},
  volume={23 13},
  pages={2564-76}
}
Pathway specificity is poorly understood for mitogen-activated protein kinase (MAPK) cascades that control different outputs in response to different stimuli. In yeast, it is not known how the same MAPK cascade activates Kss1 MAPK to promote invasive growth (IG) and proliferation, and both Fus3 and Kss1 MAPKs to promote mating. Previous work has suggested that the Kss1 MAPK cascade is activated independently of the mating G protein (Ste4)-scaffold (Ste5) system during IG. Here we demonstrate… CONTINUE READING