Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

@article{Duncan2007DifferentialI1,
  title={Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.},
  author={Raymond Scott Duncan and Sung-Yong Hwang and Peter Koulen},
  journal={The international journal of biochemistry & cell biology},
  year={2007},
  volume={39 10},
  pages={1852-62}
}
Differential intracellular distribution of the three pharmacologically and biophysically distinct types of IP3Rs can lead to different subcellular Ca2+ transients each coupled to discrete intracellular functions. Here, we report the functional localization of differentially distributed IP3 receptor types in the commonly-used hippocampal cell line HT22. The distinct subcellular localization and Ca2+ signaling properties of these receptors determine the potential role of specific IP3 receptor… CONTINUE READING

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