Differential inhibitory effects of three nitric oxide donors on ornithine decarboxylase activity in human colon carcinoma cells.

@article{Blachier1998DifferentialIE,
  title={Differential inhibitory effects of three nitric oxide donors on ornithine decarboxylase activity in human colon carcinoma cells.},
  author={François Blachier and Danielle Briand and Mohamed Selamnia and V. Schoborg Robert and Gw{\'e}na{\"e}le Guihot and Camille Mayeur},
  journal={Biochemical pharmacology},
  year={1998},
  volume={55 8},
  pages={
          1235-9
        }
}
Ornithine decarboxylase (ODC, EC 4.1.1.17) is the enzyme responsible for the synthesis of polyamines, which are absolutely necessary for cell proliferation. In the present work, we tested the effects of 3 nitric oxide (NO) donors, namely, sodium nitroprusside (SNP), (Z)-1-(N-methyl-N-[6-(N-methylammoniohexyl)amino] diazen-1-ium-1,2-diolate (MAHMA/NO) and 1,1-diethyl-2-hydroxy-2-nitroso-hydrazine sodium (DEA/NO), on ODC activity in human-colon carcinoma cells (HT-29). SNP was the most effective… CONTINUE READING
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