Differential inhibitory effects of indomethacin, dexamethasone, and interferon-gamma (IFN-gamma) on IL-11 production by rheumatoid synovial cells.

@article{Taki1998DifferentialIE,
  title={Differential inhibitory effects of indomethacin, dexamethasone, and interferon-gamma (IFN-gamma) on IL-11 production by rheumatoid synovial cells.},
  author={Hirofumi Taki and Eiji Sugiyama and Takashi Mino and Akira Kuroda and Masashi Kobayashi},
  journal={Clinical and experimental immunology},
  year={1998},
  volume={112 1},
  pages={133-8}
}
IL-11, a member of the IL-6 type cytokines, has some biological activity related to the joint destruction in rheumatoid arthritis (RA), such as induction of osteoclast differentiation. However, its expression and regulation in rheumatoid inflamed joints has not been clarified. In the present study we examined the capacity of fresh rheumatoid synovial cells (fresh RSC) to produce IL-11, and the effect of indomethacin, dexamethasone and IFN-gamma on IL-11 production. Fresh RSC obtained from eight… CONTINUE READING