Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.

@article{Seynaeve1994DifferentialIO,
  title={Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.},
  author={Caroline M. Seynaeve and Marcelo G Kazanietz and Peter M. Blumberg and Edward A. Sausville and Peter J. Worland},
  journal={Molecular pharmacology},
  year={1994},
  volume={45 6},
  pages={1207-14}
}
UCN-01 (7-hydroxystaurosporine) has been demonstrated to be a potent inhibitor of tumor cell growth both in cell culture and with in vivo xenograft models. The ability of UCN-01 to inhibit the kinase activity of recombinant protein kinase C (PKC) isozymes alpha, beta, gamma, delta, epsilon, and zeta was characterized using an in vitro kinase assay. Two distinct groups of isozymes could be defined on the basis of relative potency of kinase inhibition. UCN-01 was 15-20-fold more potent for… CONTINUE READING
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