Differential inhibition of human liver and duodenum sulphotransferase activities by quercetin, a flavonoid present in vegetables, fruit and wine

@article{Marchetti2001DifferentialIO,
  title={Differential inhibition of human liver and duodenum sulphotransferase activities by quercetin, a flavonoid present in vegetables, fruit and wine},
  author={Franco Marchetti and Chiara de Santi and Maj. Nicholas Vietri and Andrea Pietrabissa and Roberto Spisni and Franco Mosca and Gian Maria Pacifici},
  journal={Xenobiotica},
  year={2001},
  volume={31},
  pages={841 - 847}
}
1. Quercetin is a natural flavonoid present in vegetables, fruit and wine, and is known to inhibit sulphotransferase. Drugs are often taken orally and the intestinal mucosa is an early site of drug metabolism. The aims of this investigation were to study the inhibition of dopamine, (-)-salbutamol, minoxidil and paracetamol sulphation by quercetin in the duodenal mucosa and liver and to compare the IC 50 in these tissues. 2. The rates (pmol min -1 mg -1) of sulphation of 4-nitrophenol were 343… 
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