Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors.

@article{Rickards2001DifferentialIO,
  title={Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors.},
  author={Karen J. C. Rickards and Clive P Page and Peter D. Lees and Fiona M. Cunningham},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2001},
  volume={24 4},
  pages={
          275-81
        }
}
Neutrophils are recruited to the lungs of horses with chronic obstructive pulmonary disease (COPD) and exhibit increased activity after antigen challenge, which may contribute to inflammation and lung damage. Inhibition of phosphodiesterase isoenzymes (PDEs) has been shown to attenuate human neutrophil functions including superoxide production, leukotriene (LT)B4 biosynthesis, enzyme and chemokine release. As equine neutrophils contain predominantly the isoenzyme, PDE4, the present study was… CONTINUE READING
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