Differential inhibition of T cell receptor signal transduction and early activation events by a selective inhibitor of protein-tyrosine kinase.

@article{Trevillyan1990DifferentialIO,
  title={Differential inhibition of T cell receptor signal transduction and early activation events by a selective inhibitor of protein-tyrosine kinase.},
  author={James M Trevillyan and Y L Lu and D. Atluru and Catherine A. Phillips and J M Bjorndahl},
  journal={Journal of immunology},
  year={1990},
  volume={145 10},
  pages={3223-30}
}
Engagement of the TCR (CD3-Ti) by Ag/MHC, CD3 mAb, or lectin mitogen stimulates the very early tyrosine phosphorylation of several cellular substrates including TCR-zeta. The T cell specific protein-tyrosine kinase (PTK), p56lck, has been implicated in the tyrosine phosphorylation of TCR-zeta. However, the significance of this event with regard to CD3-Ti signal transduction remains unclear. Herein, we have investigated the effect of the selective PTK inhibitor genistein (4',5,7… CONTINUE READING

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