Differential inhibition of RAW264.7 macrophage tumoricidal activity by delta 9tetrahydrocannabinol.

@article{BurnetteCurley1995DifferentialIO,
  title={Differential inhibition of RAW264.7 macrophage tumoricidal activity by delta 9tetrahydrocannabinol.},
  author={D Burnette-Curley and Guy A. Cabral},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1995},
  volume={210 1},
  pages={64-76}
}
delta 9tetrahydrocannabinol (THC), the major psychoactive component of marijuana, has been shown to inhibit macrophage cell contact-dependent cytolysis of tumor cells. The purpose of this study was to determine whether THC inhibited macrophage cytolytic function by targeting selectively tumor necrosis factor (TNF)-dependent pathways versus L-arginine-dependent reactive nitrogen intermediates. An in vitro system employing RAW264.7 macrophage-like cells as effectors and TNF-sensitive mouse L929… CONTINUE READING

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