Differential influence of the 4F2 heavy chain and the protein related to b(0,+) amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter.

@article{Rajan2000DifferentialIO,
  title={Differential influence of the 4F2 heavy chain and the protein related to b(0,+) amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter.},
  author={Deva Prasanna Rajan and Wei Huang and Ramesh Kekuda and Ronald L George and Jean Wang and Simon J. Conway and Lawrence D. Devoe and Frederick H. Leibach and Puttur D Prasad and Vadivel Ganapathy},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 19},
  pages={14331-5}
}
We provide evidence here that b(0,+) amino acid transporter (b(0, +)AT) interacts with 4F2 heavy chain (4F2hc) as well as with the protein related to b(0,+) amino acid transporter (rBAT) to constitute functionally competent b(0,+)-like amino acid transport systems. This evidence has been obtained by co-expression of b(0, +)AT and 4F2hc or b(0,+)AT and rBAT in human retinal pigment epithelial cells and in COS-1 cells. The ability to interact with 4F2hc and rBAT is demonstrable with mouse b(0… CONTINUE READING

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