Differential influence of peripheral and systemic sex steroids on skeletal muscle quality in pre- and postmenopausal women.

@article{Pllnen2011DifferentialIO,
  title={Differential influence of peripheral and systemic sex steroids on skeletal muscle quality in pre- and postmenopausal women.},
  author={Eija P{\"o}ll{\"a}nen and Sarianna Sipil{\"a} and Markku Al{\'e}n and Paula H. A. Ronkainen and Carina Ankarberg-Lindgren and Jukka Puolakka and Harri Suominen and Esa H{\"a}m{\"a}l{\"a}inen and Ursula L Turpeinen and Yrj{\"o} T. Konttinen and Vuokko Kovanen},
  journal={Aging cell},
  year={2011},
  volume={10 4},
  pages={650-60}
}
Aging is associated with gradual decline of skeletal muscle strength and mass often leading to diminished muscle quality. This phenomenon is known as sarcopenia and affects about 30% of the over 60-year-old population. Androgens act as anabolic agents regulating muscle mass and improving muscle performance. The role of female sex steroids as well as the ability of skeletal muscle tissue to locally produce sex steroids has been less extensively studied. We show that despite the extensive… CONTINUE READING
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