Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice.

@article{Yamagishi2003DifferentialIO,
  title={Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice.},
  author={Shin-ichiro Yamagishi and Kenji Uehara and Saori Otsuki and Soroku Yagihashi},
  journal={Journal of neurochemistry},
  year={2003},
  volume={87 2},
  pages={
          497-507
        }
}
To explore the relationship between polyol pathway and protein kinase C (PKC), we examined PKC activities and expressions of PKC isoforms separately in endoneurial and vessel-rich epineurial tissues in diabetic mice transgenic for human aldose reductase (Tg). Tg and littermate control mice (Lm) were made diabetic by streptozotocin at 8 weeks of age and treated orally with aldose reductase inhibitor (ARI) (fidarestat 3-5 mg/kg/day) or placebo for 12 weeks. At the end, compared with non-diabetic… CONTINUE READING

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