Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor.

@article{Schulert2006DifferentialIO,
  title={Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor.},
  author={Grant S. Schulert and Lee-Ann H Allen},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={80 3},
  pages={
          563-71
        }
}
Francisella tularensis (Ft) is a Gram-negative bacterium and the causative agent of tularemia. It is well established that this organism replicates inside macrophages, but we are only beginning to understand this interface at the molecular level. Herein, we compared directly the ability of Ft subspecies holarctica live-vaccine strain to infect freshly isolated human peripheral blood monocytes, monocyte-derived macrophages (MDM), and cells of the murine macrophage cell line J774A.1 (J774). We… CONTINUE READING
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