Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage.

@article{Bianco2005DifferentialIO,
  title={Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage.},
  author={Nicole R. Bianco and Laura J. Chaplin and Monica M. Montano},
  journal={The Biochemical journal},
  year={2005},
  volume={385 Pt 1},
  pages={279-87}
}
Quinone reductase (QR) is a phase II detoxification enzyme that plays an important role in detoxifying quinones and may help maintain the antioxidant function of the cell. We have previously observed that QR is up-regulated by anti-oestrogens, but not oestrogen, in breast cancer cells via ERbeta (oestrogen receptor beta) transactivation. Such QR induction appears to protect breast cells against oestrogen-induced oxidative DNA damage, most likely by reducing reactive oestrogen metabolites termed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…